MP: Washington, Oct 25 (ANI): A research team at the Central Food
Technological Research Institute, in Mysore, India, has demonstrated
the effectiveness of a novel multi-step ulcer preventive activity.
The treatment uses a novel phenol-bound pectic polysaccharide from
Decalepis hamiltonii, plant species found in abundance in India, to
treat multiple complications encountered during ulcers.
The Indian team's remedy provides gastroprotection against swim /
alcohol stress induced ulcers in experimental animal models and
down-regulation of activated H+, K+-ATPase in the stomach tissue, that
leads to acidity.
The olysaccharide also normalises oxidative stress and oxidative
stress induced damage to the stomach tissue, and antioxidant enzymes
which necessitate the management of oxidative stress generated during
gastric ulceration, along with recovery of damaged mucosal epithelium,
which can safeguard the stomach tissue by preventing the entry of an
ulcerogenic, such as Helicobacter pylori.
The identified polysaccharide also exhibited potent antioxidant
activity, including free radical scavenging, DNA protection, and
inhibition of growth of Helicobacter pylori in vitro, confirming the
ability of the polysaccharide in inhibiting various steps of gastric
ulceration directly.
The researchers concluded that a bioactive polysaccharide from swallow
root, with defined sugar composition and phenolic antioxidant,
exhibited multi-potent free radical scavenging antioxidant, anti-H.
pylori, inhibition of H+, K+-ATPase and gastric mucosal protective
activities. Swallow root has been shown to be non-toxic, as opposed to
other known anti-ulcer drugs.
The report appears in the World Journal of Gastroenterology. (ANI)
Labels: Health
